Recombinant human SDF1 protein (ab9798)



  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP48061
    • SpeciesHuman
    • Amino acids22 to 89
    • Additional sequence informationThe sequence corresponds to the mature SDF-1 alpha protein.

Associated products


Our Abpromise guarantee covers the use of ab9798 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity

    Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/ml.

  • Applications

    Functional Studies


  • Endotoxin level< 0.100 Eu/µg
  • FormLyophilised
  • Additional notesThe biological activity of this product is determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentration range of 20.0-80.0 ng/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.


    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • ReconstitutionPlease add 100ul water to reconstitute this product.

General Info

  • Alternative names
    • 12-O-tetradecanoylphorbol 13-acetate repressed protein 1
    • AI174028
    • C-X-C motif chemokine 12
    • Chemokine (C-X-C motif) ligand 12
    • Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
    • Chemokine CXC motif ligand 12
    • cxcl12
    • hIRH
    • hSDF-1
    • Intercrine reduced in hepatomas
    • IRH
    • OTTHUMP00000019491
    • PBSF
    • Pre-B cell growth-stimulating factor
    • SCYB12
    • SDF 1
    • SDF-1
    • SDF-1-alpha(3-67)
    • SDF-1a
    • SDF-1b
    • SDF1_HUMAN
    • SDF1A
    • SDF1B
    • Stromal cell-derived factor 1
    • Stromal cell-derived factor 1 delta
    • Stromal cell-derived factor 1 gamma
    • Stromal cell-derived factor 1a
    • Stromal cell-derived factor-1 alpha
    • Thymic lymphoma cell-stimulating factor
    • Tlsf
    • TLSF-a
    • TLSF-b
    • Tlsfa
    • Tlsfb
    • TPAR1
    see all
  • FunctionChemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
  • Tissue specificityIsoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.
  • Sequence similaritiesBelongs to the intercrine alpha (chemokine CxC) family.
  • Developmental stageIsoform Alpha is ubiquitously expressed in fetal tissues. Isoform Beta and isoform Delta have more limited expression patterns, with highest levels detected in fetal spleen and fetal liver, respectively. Isoform Gamma and isoform Theta are weakly detected in fetal kidney.
  • Post-translational
    Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
  • Cellular localizationSecreted.
  • Information by UniProt

References for Recombinant human SDF1 protein (ab9798)

ab9798 has not yet been referenced specifically in any publications.

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I am sorry to hear that none of the 3 SDF1 antibodies we have are working for you. Do all 3 antibodies give you the same problem of high background and no band around 10 kDa? How were your samples prepared? And ...

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According to Uniprot, Isoform Alphais ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. It also interacts with the N-terminus of CXCR7.

Using this as a basic for cho...

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