This product is an active protein and may elicit a biological response in vivo, handle with caution.
Sentrin specific protease 2
Sentrin-specific protease 2
Sentrin/SUMO specific protease SENP2
Sentrin/SUMO-specific protease SENP2
SMT3 specific isopeptidase 2
SMT3-specific isopeptidase 2
SUMO1/sentrin/SMT3 specific peptidase 2
Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
Belongs to the peptidase C48 family.
The N-terminus is necessary and sufficient for nuclear envelope targeting.
Polyubiquitinated; which leads to proteasomal degradation.
Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.