Recombinant Human Serglycin protein (ab113401)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionP10124
    • SpeciesHuman
    • SequenceMGSSHHHHHH SSGLVPRGSH MGSHMYPTRR ARYQWVRCNP DSNSANCLEE KGPMFELLPG ESNKIPRLRT DLFPKTRIQD LNRIFPLSED YSGSGFGSGS GSGSGSGSGF LTEMEQDYQL VDESDAFHDN LRSLDRNLPS DSQDLGQHGL EEDFML
    • Molecular weight17 kDa
    • Amino acids28 to 158
    • TagsHis tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab113401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Mass spectrometry
    MALDI-TOF
  • Purity> 90 % SDS-PAGE.
    Conventional chromatography techniques (anion exchange followed by gel filtration with 20mM Tris pH 7.5, 2mM EDTA).
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.03% DTT, 0.88% Sodium chloride, 10% Glycerol

General Info

  • Alternative names
    • Chondroitin sulfate proteoglycan core protein
    • Cytolytic granule proteoglycan core protein
    • FLJ12930
    • gp600
    • Hematopoetic proteoglycan core protein
    • Mastocytoma proteoglycan core protein
    • MGC9289
    • OTTHUMP00000019716
    • P.PG
    • PG19 core protein
    • Pgsg
    • Platelet proteoglycan core protein
    • platelet proteoglycan protein core
    • PLATELET PROTEOGLYCAN PROTEIN CORE; PPG
    • PPG
    • PRG
    • PRG1
    • PROTEOGLYCAN 1
    • proteoglycan 1, secretory granule
    • Proteoglycan 10K core protein
    • Proteoglycan peptide core protein
    • PROTEOGLYCAN PROTEIN CORE FOR MAST CELL SECRETORY GRANULE
    • secretory granule proteoglycan 1
    • Secretory granule proteoglycan core peptide
    • Secretory granule proteoglycan core protein
    • Serglycin
    • serglycin proteoglycan
    • Sgc
    • Srgn
    • SRGN_HUMAN
    see all
  • FunctionPlays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
  • Sequence similaritiesBelongs to the serglycin family.
  • Post-translational
    modifications
    O-glcosylated; contains chondroitin sulfate and heparan sulfate.
  • Cellular localizationCytoplasmic granule. Secreted > extracellular space. Golgi apparatus. Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation.
  • Information by UniProt

Recombinant Human Serglycin protein images

  • 15% SDS-PAGE of SRGN protein: (1) MW ladder, (2) protein loaded 3ug

References for Recombinant Human Serglycin protein (ab113401)

ab113401 has not yet been referenced specifically in any publications.

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