FunctionMajor acute phase reactant. Apolipoprotein of the HDL complex.
Tissue specificityExpressed by the liver; secreted in plasma.
Involvement in diseaseNote=Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function. Note=Elevated serum SSA protein levels may be associated with lung cancer.
Sequence similaritiesBelongs to the SAA family.
Post-translational modificationsThis protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.