The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
Best use within three months from the date of receipt of this protein.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Serine tRNA ligase
Serine tRNA ligase 1, cytoplasmic
serine--tRNA ligase, cytoplasmic
Seryl tRNA Ser/Sec synthetase
Seryl tRNA synthetase
Seryl tRNA synthetase cytoplasmic
Seryl-tRNA Ser/Sec synthetase
seryl-tRNA synthetase, cytoplasmic
FunctionCatalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
PathwayAminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.
Sequence similaritiesBelongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.
DomainConsists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.