Histone lysine N methyltransferase H3 lysine 4 specific SET7
Histone-lysine N-methyltransferase SETD7
Lysine N-methyltransferase 7
SET domain containing (lysine methyltransferase) 7
SET domain containing protein 7
SET domain containing protein 8
SET domain-containing protein 7
FunctionHistone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated 'Lys-372' of p53/TP53 in vitro.
Tissue specificityWidely expressed. Expressed in pancreatic islets.
Sequence similaritiesBelongs to the histone-lysine methyltransferase family. SET7 subfamily. Contains 3 MORN repeats. Contains 1 SET domain.
DomainThe SET domain is necessary but not sufficient for histone methyltransferase activity.