Recombinant Human SH3BP2 protein (ab159503)

Overview

  • Product name
    Recombinant Human SH3BP2 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      PLPNSVFVNTTESCEVERLFKATSPRGEPQDGLYCIRNSSTKSGKVLVVW DETSNKVRNYRIFEKDSKFYLEGEVLFVSVGSMVEHYHTHVLPSHQSLLL RHPYGYTGPR
    • Amino acids
      452 to 561
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab159503 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 3BP-2
    • 3BP2
    • 3BP2_HUMAN
    • Abl SH3 binding protein 2
    • Cherubism
    • CRBM
    • CRPM
    • FLJ42079
    • FLJ54978
    • RES4-23
    • SH3 domain binding protein 2
    • SH3 domain-binding protein 2
    • Sh3bp2
    • TNFAIP3 interacting protein 2
    see all
  • Function
    Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism.
  • Tissue specificity
    Expressed in a variety of tissues including lung, liver, skeletal muscle, kidney and pancreas.
  • Involvement in disease
    Defects in SH3BP2 are the cause of cherubism (CRBM) [MIM:118400]. CRBM is an autosomal dominant inherited syndrome characterized by excessive bone degradation of the upper and lower jaws, which often begins around three years of age. It is followed by development of fibrous tissue masses, which causes a characteristic facial swelling.
  • Sequence similarities
    Contains 1 PH domain.
    Contains 1 SH2 domain.
  • Information by UniProt

Images

  • ab159503 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab159503 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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