The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml.
Best use within three months from the date of receipt of this protein.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.3% Glutathione
bA335L15.1 (SH3 domain GRB2 like 2)
Endophilin A1 BAR domain
SH3 domain containing GRB2 like protein 2
SH3 domain GRB2 like 2
SH3 domain protein 2A
SH3 domain-containing GRB2-like protein 2
FunctionImplicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature.
Tissue specificityBrain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Sequence similaritiesBelongs to the endophilin family. Contains 1 BAR domain. Contains 1 SH3 domain.
DomainAn N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.
Cellular localizationCytoplasm. Membrane. Concentrated in presynaptic nerve terminals in neurons.