This product is an active protein and may elicit a biological response in vivo, handle with caution.
Hematopoietic cell phosphatase
Hematopoietic cell protein tyrosine phosphatase
Hematopoietic cell protein-tyrosine phosphatase
Protein tyrosine phosphatase 1C
Protein tyrosine phosphatase non receptor type 6
Protein tyrosine phosphatase SHP1
Protein-tyrosine phosphatase 1C
protein-tyrosine phosphatase SHP 1
Protein-tyrosine phosphatase SHP-1
SH PTP 1
tyrosine protein phosphatase non receptor type 6
Tyrosine-protein phosphatase non-receptor type 6
FunctionPlays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
Tissue specificityIsoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Contains 2 SH2 domains. Contains 1 tyrosine-protein phosphatase domain.
Post-translational modificationsPhosphorylated on serine and tyrosine residues.
Cellular localizationCytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.