The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Endotoxin level< 0.100 Eu/µg
% SDS-PAGE. ab108572 is 0.2µm filtered
Additional notesWorking aliquots are stable for up to 3 months when stored at -20°C.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Ig IL1 related receptor
Single Ig IL 1 related receptor
Single Ig IL-1-related receptor
Single Ig IL-1R-related molecule
Single Ig IL1R Related Molecule
Single immunoglobulin and toll interleukin 1 receptor (TIR) domain
Single immunoglobulin and toll interleukin 1 receptor domain
Single immunoglobulin domain containing IL1R related protein
Single immunoglobulin domain IL1R1 related
Single immunoglobulin domain-containing IL1R-related protein
Toll/interleukin 1 receptor 8
Toll/interleukin-1 receptor 8
FunctionActs as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Tissue specificityMainly expressed in epithelial tissues such as kidney, lung and gut.
Sequence similaritiesBelongs to the interleukin-1 receptor family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 TIR domain.