The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
>90% by SDS-PAGE. ab169902 was expressed in E.coli as inclusion bodies, then refolded using “temperature shift inclusion body refolding” technology, chromatographically purified and sterile-filtered.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituent: 0.32% Tris HCl Note: Contains NaCl, KCl, EDTA, arginine, DTT and Glycerol
NAD dependent deacetylase sirtuin 2
NAD-dependent deacetylase sirtuin-2
NAD-dependent protein deacetylase sirtuin-2
Regulatory protein SIR2 homolog 2
Silencing information regulator 2 like
Silent information regulator 2
SIR2 like protein 2
Sir2 related protein type 2
SIR2, S. cerevisiae, homolog-loke 2
SIR2-like protein 2
Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae)
Sirtuin type 2
NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
Belongs to the sirtuin family. Contains 1 deacetylase sirtuin-type domain.
Peaks during mitosis. After mitosis, it is probably degraded by the 26S proteasome.
Phosphorylated at the G2/M transition of the cell cycle.
Cytoplasm > cytoskeleton. Colocalizes with microtubules.