NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Regulatory protein SIR2 homolog 3
Silent mating type information regulation 2 S.cerevisiae homolog 3
Sir 2 like 3
SIR 2 like protein 3
Sir2 like 3
SIR2 like protein 3
SIR2-like protein 3
Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae)
Sirtuin type 3
FunctionNAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the sirtuin family. Class I subfamily. Contains 1 deacetylase sirtuin-type domain.
Post-translational modificationsProcessed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity.