• NatureRecombinant
  • SourceBaculovirus infected Sf9 cells
  • Amino Acid Sequence
    • AccessionQ8N6T7
    • SpeciesHuman
    • Molecular weight39 kDa including tags
    • Amino acids23 to 355
    • TagsHis tag N-Terminus


Our Abpromise guarantee covers the use of ab104030 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activityThe Specific activity of ab104030 was determined to be 120 RLU/min/ng.
  • Applications


    Functional Studies

  • Purity> 90 % SDS-PAGE.
    Purity was determined to be >90% by densitometry.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: 150mM Imidazole
    Constituents: 25% Glycerol, 50mM Sodium phosphate, 300mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.0

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • 2810449N18Rik
    • AI043036
    • Mono ADP ribosyltransferase sirtuin 6
    • NAD-dependent protein deacetylase sirtuin-6
    • Regulatory protein SIR2 homolog
    • Regulatory protein SIR2 homolog 6
    • SIR2 like 6
    • SIR2 like protein 6
    • Sir2 related protein type 6
    • SIR2-like protein 6
    • SIR2L6
    • SIR6_HUMAN
    • SIRT 6
    • SIRT6
    • Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae)
    • Sirtuin 6
    • Sirtuin type 6
    • Sirtuin6
    see all
  • FunctionNAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
  • Sequence similaritiesBelongs to the sirtuin family. Class IV subfamily.
    Contains 1 deacetylase sirtuin-type domain.
  • Cellular localizationNucleus, nucleoplasm. Predominantly nuclear. Associated with telomeric heterochromatin regions.
  • Information by UniProt

Recombinant human SIRT6 protein images

  • The Specific activity of ab104030 was determined to be 120 RLU/min/ng.
  • SDS-PAGE showing ab104030 at approximately 39kDa.

References for Recombinant human SIRT6 protein (ab104030)

ab104030 has not yet been referenced specifically in any publications.

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