Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman

Specifications

Our Abpromise guarantee covers the use of ab95246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Functional Studies

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 0.05% Tween 20, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0

General Info

  • Alternative names
    • NAD dependent deacetylase sirtuin 7
    • NAD dependent protein deacetylase sirtuin 7
    • NAD-dependent protein deacetylase sirtuin-7
    • Regulatory protein SIR2 homolog 7
    • Silent mating type information regulation 2 homolog
    • Silent mating type information regulation 2 S.cerevisiae homolog 7
    • SIR2 L7
    • SIR2 like protein 7
    • Sir2 related protein type 7
    • SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7
    • SIR2-like protein 7
    • SIR2L 7
    • SIR2L7
    • SIR7_HUMAN
    • SIRT 7
    • SIRT7
    • Sirtuin 7
    • Sirtuin type 7
    • Sirtuin7
    see all
  • FunctionNAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.
  • Sequence similaritiesBelongs to the sirtuin family. Class IV subfamily.
    Contains 1 deacetylase sirtuin-type domain.
  • Post-translational
    modifications
    Phosphorylated during mitosis.
  • Cellular localizationCytoplasm. Nucleus, nucleolus. Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis.
  • Information by UniProt

Recombinant Human SIRT7 protein images

  • ab95246 at 4 µg analysed on a 10% gel by SDS PAGE followed by coomassie staining (lane 1). ab95246 is >75% pure and has a molecular weight of 46 kDa. Lane 2 contains the protein molecular weight markers.

References for Recombinant Human SIRT7 protein (ab95246)

ab95246 has not yet been referenced specifically in any publications.

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