Recombinant Human SIVA protein (denatured) (ab171470)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MGSMPKRSCP FADVAPLQLK VRVSQRELSR GVCAERYSQE VFEKTKRLLF LGAQAYLDHV WDEGCAVVHL PESPKPGPTG APRAARGQML IGPDGRLIRS LGQASEADPS GVASIACSSC VRAVDGKAVC GQCERALCGQ CVRTCWGCGS VACTLCGLVD CSDMYEKVLC TSCAMFET
    • Molecular weight
      21 kDa including tags
    • Amino acids
      1 to 175
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab171470 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 85 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    pH: 8.00
    Constituents: 2.4% Urea, 0.32% Tris HCl, 10% Glycerol

General Info

  • Alternative names
    • Apoptosis regulatory protein Siva
    • CD27 binding (Siva) protein
    • CD27-binding protein
    • CD27BP
    • Siva 1
    • Siva 2
    • SIVA_HUMAN
    • Siva1
    see all
  • Function
    Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
  • Tissue specificity
    Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon.
  • Post-translational
    modifications
    Phosphorylated by ABL2/ARG in response to oxidative stress.
  • Cellular localization
    Cytoplasm. Nucleus. In the nucleus, accumulates in dot-like structures.
  • Information by UniProt

Images

  • 15% SDS-PAGE analysis of ab171470 (3µg).

References

ab171470 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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