RNA polymerase II elongation factor like protein OCP2
RNA polymerase II elongation factor-like protein
S phase kinase associated protein 1
S phase kinase associated protein 1A
S phase kinase associated protein 1A p19A
S-phase kinase-associated protein 1
Transcription elongation factor B
Transcription Elongation Factor B 1 like
Transcription elongation factor B SIII polypeptide 1 like
FunctionEssential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.
PathwayProtein modification; protein ubiquitination.