Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab90687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Western blot

  • Purity
    > 90 % SDS-PAGE.
    ab90687 is purified using conventional chromatography techniques.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 50mM Sodium chloride, 20mM Tris HCl, pH 8.0

General Info

  • Alternative names
    • Cyclin A/CDK2 associated p19
    • Cyclin A/CDK2 associated protein p19
    • Cyclin-A/CDK2-associated protein p19
    • EMC19
    • MGC34403
    • OCP 2
    • OCP II
    • OCP II protein
    • OCP-2
    • OCP-II
    • OCP2
    • OCPII
    • Organ of Corti protein 2
    • Organ of Corti protein II
    • OTTHUMP00000159379
    • OTTHUMP00000159380
    • OTTHUMP00000228275
    • OTTHUMP00000228276
    • OTTHUMP00000228278
    • OTTHUMP00000228279
    • OTTHUMP00000228281
    • p19A
    • p19skp1
    • RNA polymerase II elongation factor like protein
    • RNA polymerase II elongation factor like protein OCP2
    • RNA polymerase II elongation factor-like protein
    • S phase kinase associated protein 1
    • S phase kinase associated protein 1A
    • S phase kinase associated protein 1A p19A
    • S-phase kinase-associated protein 1
    • SIII
    • Skp 1
    • SKP 1A
    • skp1
    • SKP1_HUMAN
    • SKP1A
    • TCEB1L
    • Transcription elongation factor B
    • Transcription Elongation Factor B 1 like
    • Transcription elongation factor B SIII polypeptide 1 like
    see all
  • Function
    Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.
  • Pathway
    Protein modification; protein ubiquitination.
  • Sequence similarities
    Belongs to the SKP1 family.
  • Information by UniProt

Images

  • 15% SDS-PAGE showing ab90687 (3µg).

References

ab90687 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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