The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Electroneutral potassium-chloride cotransporter 3
Furosemide sensitive KCl cotransporter 3
K-Cl cotransporter 3
Potassium chloride cotransporter 3
Potassium chloride cotransporter KCC3a S3
Solute carrier family 12 (potassium/chloride transporters), member 6
Solute carrier family 12 member 6
Solute carrier family 12, member 6
Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.
Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level).
Involvement in disease
Agenesis of the corpus callosum, with peripheral neuropathy