The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. This protein is best used within three months from the date of receipt.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.3% Glutathione
Chloride anion exchanger
Congenital chloride diarrhea
Down regulated in adenoma
Down regulated in adenoma protein
Down-regulated in adenoma
Solute carrier family 26 member 3
FunctionChloride/bicarbonate exchanger. Involved in absorbtion of in the colon. Helps mediate electrolyte and fluid absorption.
Involvement in diseaseDefects in SLC26A3 are the cause of diarrhea type 1 (DIAR1) [MIM:214700]; also known as congenital chloride diarrhea (CLD). DIAR1 is a disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature.
Sequence similaritiesBelongs to the SLC26A/SulP transporter (TC 2.A.53) family. Contains 1 STAS domain.
Developmental stageExpression is significantly decreased in adenomas (polyps) and adenocarcinomas of the colon.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.