The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
CMP-sialic acid transporter
Solute carrier family 35 member A1
Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function.
Involvement in disease
Defects in SLC35A1 are the cause of congenital disorder of glycosylation type 2F (CDG2F) [MIM:603585]. CDGs are a family of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.