Recombinant Human SLC37A4 protein (ab116881)

Overview

Description

  • NatureRecombinant
  • SourceWheat germ
  • Amino Acid Sequence
    • AccessionO43826
    • SpeciesHuman
    • SequenceRKTFSFVMPSLVEEIPLDKDDLGFITSSQSAAYAISKFVSGVLSDQMSA
    • Molecular weight31 kDa including tags
    • Amino acids28 to 76

Specifications

Our Abpromise guarantee covers the use of ab116881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • FormLiquid
  • Additional notesProtein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • G6PT1
    • G6PT1_HUMAN
    • G6PT2
    • G6PT3
    • Glucose-5-phosphate transporter
    • Glucose-6-phosphatase, transport (glucose) protein 3
    • Glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
    • Glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2;
    • Glucose-6-phosphate translocase
    • Glucose-6-phosphate transporter 1
    • GSD1b
    • GSD1c
    • GSD1d
    • MGC15729
    • Microsomal glucose-6-phosphate transporter
    • PRO0685
    • SLC37A4
    • Solute carrier family 37 (glucose-6-phosphate transporter), member 4
    • Solute carrier family 37 member 4
    • Transformation-related gene 19 protein
    • TRG-19
    • TRG19
    see all
  • FunctionTransports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
  • Tissue specificityMostly expressed in liver and kidney.
  • Involvement in diseaseDefects in SLC37A4 are the cause of glycogen storage disease type 1B (GSD1B) [MIM:232220]. GSD1B is a metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. GSD1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease.
    Defects in SLC37A4 are the cause of glycogen storage disease type 1C (GSD1C) [MIM:232240].
    Defects in SLC37A4 are the cause of glycogen storage disease type 1D (GSD1D) [MIM:232240].
  • Sequence similaritiesBelongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
  • Cellular localizationEndoplasmic reticulum membrane.
  • Information by UniProt

Recombinant Human SLC37A4 protein images

  • 12.5% SDS-PAGE showing ab116881 at approximately 31.02kDa stained with Coomassie Blue.

References for Recombinant Human SLC37A4 protein (ab116881)

ab116881 has not yet been referenced specifically in any publications.

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