The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Glucose-6-phosphatase, transport (glucose) protein 3
Glucose-6-phosphatase, transport (glucose-6-phosphate) protein 1
Glucose-6-phosphatase, transport (phosphate/pyrophosphate) protein 2;
Glucose-6-phosphate transporter 1
Microsomal glucose-6-phosphate transporter
Solute carrier family 37 (glucose-6-phosphate transporter), member 4
Solute carrier family 37 member 4
Transformation-related gene 19 protein
FunctionTransports glucose-6-phosphate from the cytoplasm to the lumen of the endoplasmic reticulum. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
Tissue specificityMostly expressed in liver and kidney.
Involvement in diseaseDefects in SLC37A4 are the cause of glycogen storage disease type 1B (GSD1B) [MIM:232220]. GSD1B is a metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. GSD1 patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. GSD1B patients also present a tendency towards infections associated with neutropenia, relapsing aphthous gingivostomatitis, and inflammatory bowel disease. Defects in SLC37A4 are the cause of glycogen storage disease type 1C (GSD1C) [MIM:232240]. Defects in SLC37A4 are the cause of glycogen storage disease type 1D (GSD1D) [MIM:232240].
Sequence similaritiesBelongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.