Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSTE NVEGKPSNLG ERGRARSSTF LRVVQPMFNH SIFTSAVSPA AERIRFILGE EDDSPAPPQL FTELDELLAV DGQEMEWKET ARWIKFEEKV EQGGERWSKP HVATLSLHSL FELRTCMEKG SIMLDREASS LPQLVEMIVD HQIETGLLKP ELKDKVTYTL LRKHRHQTKK SNLRSLADIG KTVSSASRMF TNPDNGSPAM THRNLTSSSL NDISDKPEKD QLKNKFMKKL PRDAEASNVL VGEVDFLDTP FIAFVRLQQA VMLGALTEVP VPTRFLFILL GPKGKAKSYH EIGRAIATLM SDEVFHDIAY KAKDRHDLIA GIDEFLDEVI VLPPGEWDPA IRIEPPKSLP SSDKRKNMYS GGENVQMNGD TPHDGGHGGG GHGDCEELQR TGRFCGGLIK DIKRKAPFFA SDFYDALNIQ
    • Amino acids1 to 424

Specifications

Our Abpromise guarantee covers the use of ab84337 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 90 % SDS-PAGE.
    ab84337 is purified using conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 0.5mM DTT, 0.1mM PMSF, pH 7.5

General Info

  • Alternative names
    • DKFZp781H1314
    • Electrogenic sodium bicarbonate cotransporter 1
    • hhNMC
    • HNBC 1
    • HNBC1
    • KNBC
    • kNBC 1
    • kNBC1
    • Na(+)/HCO3(-) cotransporter
    • Na+HCO3- cotransporter 4
    • NBC 1
    • NBC 2
    • NBC1
    • NBC2
    • Nbc4
    • NBCE 1
    • NBCE1
    • OTTHUMP00000160355
    • OTTHUMP00000218884
    • OTTHUMP00000218885
    • PNBC
    • S4A4_HUMAN
    • SLC4A4
    • SLC4A5
    • Sodium bicarbonate cotransporter
    • Sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas)
    • Sodium bicarbonate cotransporter kidney
    • sodium bicarbonate cotransporter member 4
    • Sodium bicarbonate cotransporter pancreas
    • Solute carrier family 4 member 4
    • Solute carrier family 4 sodium bicarbonate cotransporter member 4
    • Solute carrier family 4 sodium bicarbonate cotransporter member 5
    • Solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type
    see all
  • FunctionElectrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
  • Tissue specificityIsoform 1 is expressed in pancreas and to a lower extent in heart, skeletal muscle, liver, parotid salivary glands, prostate, colon, stomach, thyroid, brain and spinal chord. Corneal endothelium cells express only isoform 1 (at protein level). Isoform 2 is specifically expressed in kidney at the level of proximal tubules.
  • Involvement in diseaseDefects in SLC4A4 are the cause of proximal renal tubular acidosis with ocular abnormalities (pRTA-OA) [MIM:604278]; also known as renal tubular acidosis II. Caused by an impairment of bicarbonate absorption in the proximal tubule, proximal renal tubular acidosis (pRTA) is characterized by a decreased renal HCO3(-) threshold. pRTA-OA is an extremely rare autosomal recessive syndrome characterized by short stature, profound pRTA, mental retardation, bilateral glaucoma, cataracts and bandkeratopathy.
    Note=Loss of interaction with and stimulation by CA4 is the cause of retinitis pigmentosa type 17 (RP17).
  • Sequence similaritiesBelongs to the anion exchanger (TC 2.A.31) family.
  • Post-translational
    modifications
    Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylation of Thr-49 regulates isoform 1 conductance.
    N-glycosylation is not necessary for the transporter basic functions.
  • Cellular localizationBasolateral cell membrane.
  • Information by UniProt

Recombinant Human SLC4A4 protein images

  • 15% SDS-PAGE showing ab84337 at approximately 51.5kDa (3µg).

References for Recombinant Human SLC4A4 protein (ab84337)

ab84337 has not yet been referenced specifically in any publications.

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