The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
Concentration information loading...
Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Neurotransmitter transporter RB21A
Neurotransmitter transporter rB21A homolog
Orphan transporter XT3
Sodium and chloride dependent transporter XTRP3
Sodium- and chloride-dependent transporter XTRP3
Sodium/imino acid transporter 1
Sodium/imino-acid transporter 1
Solute carrier family 6 (neurotransmitter transporter) member 20
Solute carrier family 6 (proline IMINO transporter) member 20
Solute carrier family 6 member 20
Transporter rB21A homolog
X transporter protein 3
Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Involved in the transport of glycine.
Kidney and small intestine. Expressed in the S3 segment of the proximal tubule.
Involvement in disease
Defects in SLC6A20 are a cause of hyperglycinuria (HG) [MIM:138500]. It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. Defects in SLC6A20 are a cause of iminoglycinuria (IG) [MIM:242600]. It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Note=Haploinsufficiency of SLC6A20 combined with deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families.
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily.
Apical cell membrane. Located in the apical brush border membrane of kidney proximal tubule cells.