Overview

  • Product name
    Recombinant Human SLU7 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MSATVVDAVNAAPLSGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPA EVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGE WYKRGVKENSVITKYRKGACENCGAMTHKKKDCFERPRRVGAKFTGTNIA PDEHVQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKL QEELASGKLVEQANSPKHQWGEEEPNSQTEKDHNSEDEDEDKYADDIDMP GQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANA GKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKL ELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEY SRHGTVIKGQERAVACSKYEEDVKIHNHTHIWGSYWKEGRWGYKCCHSFF KYSYCTGEAGKEIVNSEECIINEITGEESVKKPQTLMELHQEKLKEEKKK KKKKKKKHRKSSSDSDDEEKKHEKLKKALNAEEARLLHVKETMQIDERKR PYNSMYETREPTEEEMEAYRMKRQRPDDPMASFLGQ
    • Amino acids
      1 to 586
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab161049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 9G8
    • hSlu7
    • MGC9280
    • Pre mRNA splicing factor SLU7
    • Pre-mRNA-splicing factor slu7
    • SLU 7
    • slu7
    • SLU7 splicing factor homolog
    • SLU7 splicing factor homolog (S. cerevisiae)
    • SLU7_HUMAN
    • splicing factor
    • Step II splicing factor SLU7
    • Zinc knuckle motif containing
    see all
  • Function
    Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
  • Sequence similarities
    Belongs to the SLU7 family.
    Contains 1 CCHC-type zinc finger.
  • Domain
    The CCHC-type zinc finger is required to retain the protein within the nucleus and prevent its shuttle back to the cytoplasm via the CRM1 pathway.
  • Cellular localization
    Nucleus. Cytoplasm. Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing.
  • Information by UniProt

Images

  • ab161049 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab161049 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab161049.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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