Recombinant Human Smac / Diablo protein (ab116425)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      56 kDa including tags
    • Amino acids
      1 to 239

Specifications

Our Abpromise guarantee covers the use of ab116425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    ELISA

    SDS-PAGE

    Mass Spectrometry

  • Mass spectrometry
    MALDI-TOF-TOF
  • Purity
    > 90 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.40
    Constituent: 99% PBS

General Info

  • Alternative names
    • 0610041G12Rik
    • DBLOH_HUMAN
    • DBOH
    • DFNA64
    • diablo
    • Diablo homolog
    • Diablo homolog (Drosophila)
    • Diablo homolog mitochondrial
    • Diablo IAP binding mitochondrial protein
    • Diablo like protein
    • DIABLO S
    • Direct IAP binding protein with low pI
    • Direct IAP-binding protein with low pI
    • FLJ10537
    • FLJ25049
    • mitochondrial
    • Mitochondrial Smac protein
    • Second mitochondria derived activator of caspase
    • Second mitochondria-derived activator of caspase
    • Smac
    • SMAC 3
    • Smac protein
    • SMAC3
    see all
  • Function
    Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).
  • Tissue specificity
    Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.
  • Domain
    The mature N-terminus mediates interaction with XIAP.
  • Cellular localization
    Mitochondrion. Released into the cytosol when cells undergo apoptosis.
  • Information by UniProt

Images

  • 10% SDS-PAGE stained with Coomassie Blue (Lane 1), immunobloting with anti-6xHis (Lane 2)

References

ab116425 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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