Recombinant Human Smac / Diablo protein (ab87721)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMASMTGGQQM GRGSMAVPIA QKSEPHSLSS EALMRRAVSL VTDSTSTFLS QTTYALIEAI TEYTKAVYTL TSLYRQYTSL LGKMNSEEED EVWQVIIGAR AEMTSKHQEY LKLETTWMTA VGLSEMAAEA AYQTGADQAS ITARNHIQLV KLQVEEVHQL SRKAETKLAE AQIEELRQKT QEEGEERAES EQEAYLRED

Specifications

Our Abpromise guarantee covers the use of ab87721 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab87721 is purified by conventional chromatography techniques.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20mM Tris, pH 7.5

General Info

  • Alternative names
    • 0610041G12Rik
    • DBLOH_HUMAN
    • DBOH
    • DFNA64
    • diablo
    • Diablo homolog
    • Diablo homolog (Drosophila)
    • Diablo homolog mitochondrial
    • Diablo IAP binding mitochondrial protein
    • Diablo like protein
    • DIABLO S
    • Direct IAP binding protein with low pI
    • Direct IAP-binding protein with low pI
    • FLJ10537
    • FLJ25049
    • mitochondrial
    • Mitochondrial Smac protein
    • Second mitochondria derived activator of caspase
    • Second mitochondria-derived activator of caspase
    • Smac
    • SMAC 3
    • Smac protein
    • SMAC3
    see all
  • FunctionPromotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP).
  • Tissue specificityUbiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.
  • DomainThe mature N-terminus mediates interaction with XIAP.
  • Cellular localizationMitochondrion. Released into the cytosol when cells undergo apoptosis.
  • Information by UniProt

Recombinant Human Smac / Diablo protein images

  • 15% SDS-PAGE analysis of 3µg ab87721.

References for Recombinant Human Smac / Diablo protein (ab87721)

ab87721 has not yet been referenced specifically in any publications.

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