Overview

  • Product name
    Recombinant Human Smek1 protein
  • Protein length
    Full length protein

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSL LLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQV QGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASS LPSPLRREKLALALENEGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIF LLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVI PISDPELKQKIHQTYRVQYIQDMVLPTPSVFEENMLSTLHSFIFFNKVEI VGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQPQNR DAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYNPSMVREFV MQEAQQNDDVSKKLTEQKITSKDILLINLIIEHMICDTDPELGGAVQLMG LLRTLVDPENMLATANKTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSK DDFQTAQLLALVLELLTFCVEHHTYHIKNYIINKDILRRVLVLMASKHAF LALCALRFKRKIIGLKDEFYNRYIMKSFLFEPVVKAFLNNGSRYNLMNSA IIEMFEFIRVEDIKSLTAHVIENYWKALEDVDYVQTFKGLKLRFEQQRER QDNPKLDSMRSILRNHRYRRDARTLEDEEEMWFNTDEDDMEDGEAVVSPS DKTKNDDDIMDPISKFMERKKLKESEEKEVLLKTNLSGRQSPSFKLSLSS GTKTNLTSQSSTTNLPGSPGSPGSPGSPGSPGSVPKNTSQTAAITTKGGL VGLVDYPDDDEDDDEDEDKEDTLPLSKKAKFDS
    • Amino acids
      1 to 833
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163173 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • FLFL1
    • KIAA2010
    • MEK1 SUPPRESSOR 1
    • MSTP033
    • P4R3A_HUMAN
    • PP4R3
    • PP4R3 ALPHA
    • PP4R3A
    • PPP4R3A
    • Protein phosphatase 4 regulatory subunit 3A
    • PROTEIN PHOSPHATASE 4, REGULATORY SUBUNIT 3, ALPHA
    • Serine/threonine-protein phosphatase 4 regulatory subunit 3A
    • SMEK homolog 1
    • SMEK homolog 1, suppressor of mek1 (Dictyostelium)
    • smek1
    • Smk 1
    • SMK1
    see all
  • Function
    Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
  • Sequence similarities
    Belongs to the SMEK family.
    Contains 1 WH1 domain.
  • Cellular localization
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
  • Information by UniProt

Images

  • ab163173 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163173 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab163173.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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