Overview

  • Product name
    Recombinant Human SNIP1 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVF QYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDT SEIDRKDDED EEEEEEVSDS
    • Molecular weight
      19 kDa including tags
    • Amino acids
      258 to 396
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab124986 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity
    > 90 % SDS-PAGE.
    ab124986 is purified by proprietary chromatographic techniques.
  • Form
    Liquid
  • Additional notes
    ab124986 should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.

    pH: 8.00
    Constituents: 0.03% DTT, 0.32% Tris HCl, 20% Glycerol, 0.58% Sodium chloride

General Info

  • Alternative names
    • FHA domain containing protein SNIP1
    • FHA domain-containing protein SNIP1
    • FLJ12553
    • PMRED
    • Smad nuclear interacting protein
    • Smad nuclear interacting protein (Smad nuclear interacting)
    • smad nuclear interacting protein 1
    • Smad nuclear-interacting protein 1
    • SNIP1
    • SNIP1 (Smad nuclear interacting protein)
    • SNIP1_HUMAN
    • Splicing factor arginine/serine rich 4 (Pre mRNA splicing factor SRP75)
    see all
  • Function
    Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis.
  • Tissue specificity
    Ubiquitous, with highest expression in heart and skeletal muscle.
  • Sequence similarities
    Contains 1 FHA domain.
  • Post-translational
    modifications
    Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex.
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References for Recombinant Human SNIP1 protein (ab124986)

ab124986 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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