Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Species
      Human

Specifications

Our Abpromise guarantee covers the use of ab40262 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Mass Spectrometry

    SDS-PAGE

  • Purity
    > 95 % SDS-PAGE.

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: 0.002% Sodium Azide
    Constituents: 10mM Tris, 0.1% Triton X-100, pH 8

General Info

  • Alternative names
    • 0910001N05Rik
    • 1810032P22Rik
    • AU019504
    • D2Ertd52e
    • FLJ10931
    • OTTHUMP00000030340
    • OTTHUMP00000062927
    • OTTMUSP00000003367
    • OTTMUSP00000003368
    • RP11-504H3.2
    • RP23-35E16.2
    • snoRNA MBI-43
    • SNX 5
    • SNX5
    • SNX5_HUMAN
    • Sorting nexin 5
    • Sorting nexin-5
    see all
  • Function
    May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.
  • Sequence similarities
    Belongs to the sorting nexin family.
    Contains 1 BAR domain.
    Contains 1 PX (phox homology) domain.
  • Domain
    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate.
  • Cellular localization
    Early endosome membrane. Cell membrane. Cytoplasmic vesicle membrane. Cytoplasm. Cell projection > phagocytic cup. Cell projection > ruffle. Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation.
  • Information by UniProt

Images

  • Analysis of SNX5 Recombinant Protein. 4-20% SDS gradient gel. Coomassie blue staining shows a band around 47kDa.

References

ab40262 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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