This product is an active protein and may elicit a biological response in vivo, handle with caution.
ReconstitutionReconstitute in water
to a concentration of 0.1-1.0 mg/ml
Basement membrane protein 40
Basement-membrane protein 40
Cysteine rich protein
Secreted acidic cystein rich glycoprotein
Secreted protein acidic and rich in cysteine
Secreted protein acidic cysteine rich
Secreted protein acidic cysteine rich (osteonectin)
FunctionAppears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Sequence similaritiesBelongs to the SPARC family. Contains 1 EF-hand domain. Contains 1 follistatin-like domain. Contains 1 Kazal-like domain.
Developmental stageExpressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair.
Cellular localizationSecreted > extracellular space > extracellular matrix > basement membrane. In or around the basement membrane.