Recombinant Human Spasmolytic Polypeptide protein (ab116426)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      EKPSPCQCSR LSPHNRTNCG FPGITSDQCF DNGCCFDSSV TGVPWCFHPL PKQESDQCVM EVSDRRNCGY PGISPEECAS RKCCFSNFIF EVPWCFFPKSVEDCHY
    • Molecular weight
      12 kDa
    • Amino acids
      24 to 129

Associated products

Specifications

Our Abpromise guarantee covers the use of ab116426 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Determined by its ability to chemoattract human MCF-7 cells using a concentration 1.0-10.0 ng/ml.
  • Applications

    Functional Studies

    SDS-PAGE

    HPLC

  • Purity
    > 95 % SDS-PAGE.
    Purified by proprietary chromatographic techniques. Purity greater than 97.0% as determined by RP-HPLC.
  • Form
    Lyophilised
  • Additional notes
    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Determined by its ability to chemoattract human MCF-7 cells using a concentration 1.0-10.0 ng/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 7.40
    Constituent: PBS

  • Reconstitution
    Reconstitute the lyophilized TFF2 in sterile 18MOhm-cm H2O not less than 100µg/ml

General Info

  • Alternative names
    • SML 1
    • SML1
    • SP
    • Spasmolysin
    • Spasmolytic polypeptide
    • spasmolytic protein 1
    • TFF 2
    • TFF2
    • TFF2_HUMAN
    • Trefoil factor 2
    • trefoil factor 2 (spasmolytic protein 1)
    • Trefoil factor 2 precursor
    see all
  • Function
    Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains.
  • Tissue specificity
    Stomach.
  • Sequence similarities
    Contains 2 P-type (trefoil) domains.
  • Cellular localization
    Secreted.
  • Information by UniProt

References

ab116426 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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