The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Arsenite related gene 1 protein
Arsenite-related gene 1 protein
Coiled coil domain containing 99
Coiled-coil domain-containing protein 99
rhabdomyosarcoma antigen MU RMS 40.4A
Rhabdomyosarcoma antigen MU-RMS-40.4A
Rrhabdomyosarcoma antigen protein MU RMS 40.4A
Spindle apparatus coiled coil domain containing protein 1
Spindle apparatus coiled coil protein 1
Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.
Belongs to the Spindly family.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Cytoplasm > cytoskeleton > centrosome. Chromosome > centromere > kinetochore. Nucleus. Cytoplasm > cytoskeleton > spindle pole. Localizes to the nucleus in interphase and to the kinetochore in early prometaphase. Relocalizes to the mitotic spindle pole before metaphase and is subsequently lost from the spindle poles after chromosome congression is completed. Removal of this protein from the kinetochore requires the dynein/dynactin complex.