The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
pH: 8.0 Constituents: 0.32% Tris HCl, 10% Glycerol
EVH1 domain-containing protein 1
EVH1/Sprouty domain containing protein
protein phosphatase 1 regulatory subunit 147
Sprouty related EVH1 domain containing 1
sprouty related EVH1 domain containing protein 1
Sprouty related protein 1 with EVH 1 domain
Suppressor of Ras/MAPK activation
Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow.
Weakly expressed in embryonic cell line (HEK-293).
Involvement in disease
Defects in SPRED1 are the cause of Legius syndrome (LEGIUSS) [MIM:611431]. It is a disorder characterized mainly by cafe au lait macules without neurofibromas or other tumor manifestations of neurofibromatosis type 1, axillary freckling, and macrocephaly. Additional clinical manifestations include Noonan-like facial dysmorphism, lipomas, learning disabilities and attention deficit-hyperactivity.