Recombinant Human SQSTM1 / p62 protein (ab95320)

Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMAMSYVKDDI FRIYIKEKKE CRRDHRPPCA QEAPRNMVHP NVICDGCNGP VVGTRYKCSV CPDYDLCSVC EGKGLHRGHT KLAFPSPFGH LSEGFSHSRW LRKVKHGHFG WPGWEMGPPG NWSPRPPRAG EARPGPTAES ASGPSEDPSV NFLKNVGESV AAALSPLGIE VDIDVEHGGK RSRLTPVSPE SSSTEEKSSS QPSSCCSDPS KPGGNVEGAT QSLAEQMRKI ALESEGRPEE QMESDNCSGG DDDWTHLSSK EVDPSTGELQ SLQMPESEGP SSLDPSQEGP TGLKEAALYP HLPPEADPRL IESLSQMLSM GFSDEGGWLT RLLQTKNYDI GAALDTIQYS KHPPPLLEHH HHHH
    • Amino acids1 to 356

Specifications

Our Abpromise guarantee covers the use of ab95320 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

    Mass Spectrometry

  • Purity> 90 % SDS-PAGE.
    ab95320 is purified using conventional chromatography techniques
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • A170
    • EBI 3 associated protein of 60 kDa
    • EBI 3 associated protein p60
    • EBI3 associated protein of 60 kDa
    • EBI3 associated protein p60
    • EBI3-associated protein of 60 kDa
    • EBIAP
    • FTDALS3
    • MGC127197
    • ORCA
    • OSF-6
    • Osi
    • OSIL
    • Oxidative stress induced like
    • p60
    • p62
    • p62B
    • Paget disease of bone 3
    • PDB 3
    • PDB3
    • Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa
    • Phosphotyrosine independent ligand for the Lck SH2 domain p62
    • Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
    • PKC-zeta-interacting protein
    • Protein kinase C-zeta-interacting protein
    • Sequestosome 1
    • Sequestosome-1
    • SQSTM 1
    • SQSTM_HUMAN
    • Sqstm1
    • STAP
    • STONE14
    • Ubiquitin binding protein p62
    • Ubiquitin-binding protein p62
    • ZIP
    • ZIP 3
    • ZIP3
    see all
  • FunctionAdapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels.
  • Tissue specificityUbiquitously expressed.
  • Involvement in diseaseDefects in SQSTM1 are a cause of Paget disease of bone (PDB) [MIM:602080]. PDB is a metabolic bone disease affecting the axial skeleton and characterized by focal areas of increased and disorganized bone turn-over due to activated osteoclasts. Manifestations of the disease include bone pain, deformity, pathological fractures, deafness, neurological complications and increased risk of osteosarcoma. PDB is a chronic disease affecting 2 to 3% of the population above the age of 40 years.
  • Sequence similaritiesContains 1 OPR domain.
    Contains 1 UBA domain.
    Contains 1 ZZ-type zinc finger.
  • DomainThe UBA domain binds specifically 'Lys-63'-linked polyubiquitin chains of polyubiquitinated substrates. Mediates the interaction with TRIM55.
    The OPR domain mediates homooligomerization and interactions with PRKCZ, PRKCI, MAP2K5 and NBR1.
    The ZZ-type zinc finger mediates the interaction with RIPK1.
  • Post-translational
    modifications
    Phosphorylated. May be phosphorylated by PRKCZ (By similarity). Phosphorylated in vitro by TTN.
  • Cellular localizationCytoplasm. Late endosome. Nucleus. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Localizes to late endosomes. May also localize to the nucleus. Accumulates in neurofibrillary tangles and in Lewy bodies of neurons from individuals with Alzheimer and Parkinson disease respectively. Enriched in Rosenthal fibers of pilocytic astrocytoma. In liver cells, accumulates in Mallory bodies associated with alcoholic hepatitis, Wilson disease, indian childhood cirrhosis and in hyaline bodies associated with hepatocellular carcinoma.
  • Information by UniProt

Recombinant Human SQSTM1 / p62 protein images

  • ab95320 at 3 µg on an SDS-PAGE gel (15%).

References for Recombinant Human SQSTM1 / p62 protein (ab95320)

ab95320 has not yet been referenced specifically in any publications.

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