Calcium binding protein amplified in mutlidrug resistant cells
Sorcin (class 4 gene)
FunctionCalcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Tissue specificityDetected in cardiac myocytes.
Sequence similaritiesContains 4 EF-hand domains.
Cellular localizationCytoplasm. Sarcoplasmic reticulum membrane. Relocates to the sarcoplasmic reticulum membrane in response to elevated calcium levels.