Recombinant Human SRD5A2 protein (ab114946)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      AKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPA
    • Molecular weight
      30 kDa including tags
    • Amino acids
      28 to 65

Specifications

Our Abpromise guarantee covers the use of ab114946 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 3 oxo 5 alpha steroid 4 dehydrogenase 2
    • 3-oxo-5-alpha-steroid 4-dehydrogenase 2
    • 5 alpha SR2
    • 5 alpha-SR2
    • 5ART2
    • e II 5 alpha reductase
    • EC
    • MGC138457
    • Micropenis, included
    • S5A2_HUMAN
    • S5AR 2
    • SR type 2
    • SRD5A2
    • Steroid 5 alpha reductase 2
    • Steroid 5-alpha-reductase 2
    • Steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
    • Type II 5-alpha reductase
    see all
  • Function
    Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
  • Tissue specificity
    Expressed in high levels in the prostate and many other androgen-sensitive tissues.
  • Involvement in disease
    Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum.
  • Sequence similarities
    Belongs to the steroid 5-alpha reductase family.
  • Cellular localization
    Microsome membrane. Endoplasmic reticulum membrane.
  • Information by UniProt

Images

  • 12.5% SDS-PAGE showing ab114946 at approximately 29.81kDa.
    Stained with Coomassie Blue.

References

ab114946 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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