Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Sequence
      MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKH GPGRWVVLAAVLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNEN FVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGS VIAYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFP TDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHARCQWALRG DADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGT FNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKD YVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSS DPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKF CKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDC GDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNW LVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISH PFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGW GHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDS CQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIK ENTGV
    • Molecular weight
      120 kDa including tags
    • Amino acids
      1 to 855

Associated products

Specifications

Our Abpromise guarantee covers the use of ab114597 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    SDS-PAGE

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Epithin
    • HAI
    • Matriptase
    • Membrane type serine protease
    • Membrane type serine protease 1
    • Membrane-type serine protease 1
    • MT SP1
    • MT-SP1
    • MTSP 1
    • MTSP1
    • Prostamin
    • PRSS 14
    • PRSS14
    • Serine protease 14
    • Serine protease TADG 15
    • Serine protease TADG-15
    • Serine protease TADG15
    • SNC 19
    • SNC19
    • ST 14
    • ST14
    • ST14_HUMAN
    • Suppression of tumorigenicity 14
    • Suppression of tumorigenicity 14 (colon carcinoma matriptase epithin)
    • Suppression of tumorigenicity 14 (colon carcinoma)
    • Suppressor of tumorigenicity 14 protein
    • Suppressor of tumorigenicity protein 14
    • TADG 15
    • TADG15
    • TMPRSS14
    • Tumor associated differentially expressed gene 15 protein
    • Tumor-associated differentially-expressed gene 15 protein
    see all
  • Function
    Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
  • Involvement in disease
    Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.
  • Sequence similarities
    Belongs to the peptidase S1 family.
    Contains 2 CUB domains.
    Contains 4 LDL-receptor class A domains.
    Contains 1 peptidase S1 domain.
  • Cellular localization
    Membrane.
  • Information by UniProt

Images

  • ab114597 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

References

ab114597 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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