The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notesProtein concentration is above or equal to 0.05 mg/ml. Best used within three months from the date of receipt.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.3% Glutathione, 0.79% Tris HCl
Membrane type serine protease
Membrane type serine protease 1
Membrane-type serine protease 1
Serine protease 14
Serine protease TADG 15
Serine protease TADG-15
Serine protease TADG15
Suppression of tumorigenicity 14
Suppression of tumorigenicity 14 (colon carcinoma matriptase epithin)
Suppression of tumorigenicity 14 (colon carcinoma)
Suppressor of tumorigenicity 14 protein
Suppressor of tumorigenicity protein 14
Tumor associated differentially expressed gene 15 protein
Tumor-associated differentially-expressed gene 15 protein
FunctionDegrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
Involvement in diseaseDefects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.
Sequence similaritiesBelongs to the peptidase S1 family. Contains 2 CUB domains. Contains 4 LDL-receptor class A domains. Contains 1 peptidase S1 domain.