Recombinant Human Stabilin 2 protein (ab163129)

Overview

  • Product name
    Recombinant Human Stabilin 2 protein
  • Protein length
    Protein fragment

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      ERLRELNTEPRGKWQGRLTSFISLLDKAYAWPLSKLGPFTVLLPTDKGLK GFNVNELLVDNKAAQYFVKLHIIAGQMNIEYMNNTDMFYTLTGKSGEIF
    • Amino acids
      367 to 465
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab163129 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • 190 kDa form stabilin-2
    • 190 kDa hyaluronan receptor for endocytosis
    • EGF-like
    • FAS1 EGF-like and X-link domain-containing adhesion molecule 2
    • Fasciclin
    • FEEL-2
    • FEEL2
    • FELL
    • FEX2
    • HARE
    • Hyaluronan receptor for endocytosis
    • laminin-type EGF-like and link domain-containing scavenger receptor 2
    • link domain-containing scavenger receptor 2
    • STAB-2
    • Stab2
    • STAB2_HUMAN
    see all
  • Function
    Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalisation as well as HA and CS.
  • Tissue specificity
    Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
  • Sequence similarities
    Contains 17 EGF-like domains.
    Contains 7 FAS1 domains.
    Contains 2 laminin EGF-like domains.
    Contains 1 Link domain.
  • Domain
    Recognizes phosphatidyl serine via its epidermal growth factor-like domains.
  • Post-translational
    modifications
    Glycosylated.
    Proteolytically processed to yield a 190 kDa protein.
  • Cellular localization
    Cell membrane. Cytoplasm. Only a small amount appears to be present at the cell surface.
  • Information by UniProt

Images

  • ab163129 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab163129 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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