Recombinant Human Stathmin 1 protein (ab125559)

Overview

Description

  • Nature
    Recombinant
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      19 kDa
    • Amino acids
      1 to 149
    • Tags
      His tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab125559 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    SDS-PAGE

  • Purity
    > 90 % Densitometry.
    ab125559 is >90% pure.
  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.00
    Preservative: 1.02% Imidazole
    Constituents: 1.75% Sodium chloride, 25% Glycerol, 0.004% DTT, 0.81% Sodium phosphate, 0.002% PMSF

General Info

  • Alternative names
    • C1orf215
    • Lag
    • LAP 18
    • LAP18
    • Leukemia associated phosphoprotein p18
    • Leukemia-associated phosphoprotein p18
    • Metablastin
    • Oncoprotein 18
    • OP 18
    • Op18
    • p18
    • p19
    • Phosphoprotein 19
    • Phosphoprotein p19
    • pp17
    • pp19
    • PR22
    • Pr22 protein
    • Prosolin
    • Protein Pr22
    • SMN
    • Stathmin
    • Stathmin1
    • STMN 1
    • Stmn1
    • STMN1_HUMAN
    see all
  • Function
    Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear.
  • Tissue specificity
    Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia.
  • Sequence similarities
    Belongs to the stathmin family.
    Contains 1 SLD (stathmin-like) domain.
  • Post-translational
    modifications
    Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization (By similarity). Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity.
  • Cellular localization
    Cytoplasm > cytoskeleton.
  • Information by UniProt

Images

  • SDS PAGE analysis of ab125559 (Stathmin 1 protein).

References

ab125559 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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