Overview

Description

  • Nature
    Recombinant
  • Source
    Baculovirus infected Sf9 cells
  • Amino Acid Sequence
    • Accession
    • Species
      Human
    • Molecular weight
      76 kDa including tags
    • Amino acids
      1 to 426

Associated products

Specifications

Our Abpromise guarantee covers the use of ab125588 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    The specific activity of ab125588 was determined to be 11 nmol/min/mg.
  • Applications

    Western blot

    Functional Studies

    SDS-PAGE

  • Form
    Liquid
  • Additional notes

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • C86992
    • Serine/threonine kinase 25
    • Serine/threonine kinase 25 (STE20 homolog, yeast)
    • Serine/threonine kinase 25 (STE20 homolog, yeast), isoform CRA_a
    • Serine/threonine kinase 25 (yeast)
    • Serine/threonine protein kinase 25
    • Serine/threonine-protein kinase 25
    • SOK 1
    • SOK-1
    • SOK1
    • Ste20 like kinase
    • Ste20 yeast homolog
    • Ste20-like
    • STE20-like kinase
    • Ste20/oxidant stress response kinase 1
    • Sterile 20 (oxidant stress response kinase 1)
    • Sterile 20/oxidant stress-response kinase 1
    • STK25
    • STK25_HUMAN
    • Yeast Sps1/Ste20 related kinase 1
    • YSK 1
    • YSK1
    see all
  • Function
    Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration.
  • Tissue specificity
    Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.
  • Sequence similarities
    Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization
    Cytoplasm. Golgi apparatus. Localizes to the Golgi apparatus.
  • Information by UniProt

Images

  • SDS Page analysis of ab125588
  • The specific activity of ab125588 was determined to be 11 nmol/min/mg

References

ab125588 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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