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Alternative names
- Apoptosis inducing protein TRICK2A 2B
- Apoptosis inducing protein TRICK2A/2B
- Apoptosis inducing receptor TRAIL R2
- CD262
- CD262 antigen
- Cytotoxic TRAIL receptor 2
- Death domain containing receptor for TRAIL Apo 2L
- Death receptor 5
- DR5
- Fas like protein
- Killer
- Killer DR5
- KILLER/DR5
- p53 regulated DNA damage inducible cell death receptor killer
- p53 regulated DNA damage inducible cell death receptor(killer)
- TNF receptor superfamily member 10b
- TNF related apoptosis inducing ligand receptor 2
- TNF-related apoptosis-inducing ligand receptor 2
- TNFRSF10B
- TR10B_HUMAN
- Trail R2
- TRAIL receptor 2
- TRAIL-R2
- TRAILR2
- TRICK2
- TRICK2A
- TRICK2B
- TRICKB
- Tumor necrosis factor receptor like protein ZTNFR9
- Tumor necrosis factor receptor superfamily member 10B
- Tumor necrosis factor receptor superfamily, member 10b
- ZTNFR9
see all
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Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
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Tissue specificity
Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain.
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Involvement in disease
Squamous cell carcinoma of the head and neck
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Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.
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Cellular localization
Membrane.
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Information by UniProt