The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Protein concentration is above or equal to 0.05 mg/ml.
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Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.31% Glutathione, 0.79% Tris HCl
Cbl interacting protein p70
Cbl interacting protein Sts 1
Cbl interacting protein Sts1
Cbl-interacting protein p70
Nm23 phosphorylated unknown substrate
SH3 domain containing 70 kDa protein
Suppressor of T cell receptor signaling 1
Suppressor of T-cell receptor signaling 1
T-cell ubiquitin ligand 2
Tyrosine-protein phosphatase STS1/TULA2
Ubiquitin associated and SH3 domain containing B
Ubiquitin-associated and SH3 domain-containing protein B
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.