Recombinant human Superoxide Dismutase 1 protein (ab90040)



  • Nature
  • Source
    Escherichia coli
  • Amino Acid Sequence
    • Accession
    • Species


Our Abpromise guarantee covers the use of ab90040 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Biological activity
    Activity: > 2.000 units/mg (One unit is defined as the amount of enzyme that will double the rate of autoxidation of 5,6,6a,11b-tetrahydro - 3,9,10-trihydroxybenzo-[c]-fluorene per minute at 37oC, pH 8.8).
  • Applications


    Functional Studies

    Western blot

  • Purity
    > 90 % SDS-PAGE.

  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 50mM Sodium citrate, 1mM DTT, 0.2mM Zinc sulphate, 0.2mM Copper sulphate, pH 5.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

General Info

  • Alternative names
    • ALS
    • ALS1
    • Amyotrophic lateral sclerosis 1 adult
    • Cu/Zn SOD
    • Cu/Zn superoxide dismutase
    • Epididymis secretory protein Li 44
    • HEL S 44
    • Homodimer
    • hSod1
    • Indophenoloxidase A
    • IPOA
    • Mn superoxide dismutase
    • SOD
    • SOD soluble
    • SOD1
    • SOD2
    • SODC
    • Superoxide dismutase [Cu-Zn]
    • Superoxide dismutase 1
    • Superoxide dismutase 1 soluble
    • Superoxide dismutase Cu Zn
    • Superoxide dismutase cystolic
    see all
  • Function
    Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
  • Involvement in disease
    Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
  • Sequence similarities
    Belongs to the Cu-Zn superoxide dismutase family.
  • Post-translational
    Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation. The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
    The ditryptophan cross-link at Trp-33 is reponsible for the non-disulfide-linked homodimerization. Such modification might only occur in extreme conditions and additional experimental evidence is required.
  • Cellular localization
    Cytoplasm. The pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
  • Information by UniProt

Recombinant human Superoxide Dismutase 1 protein images

  • Developed using the ECL technique

    Performed under reducing conditions.

  • Developed using the ECL technique

    Performed under reducing conditions.

    Exposure time : 4 minutes

References for Recombinant human Superoxide Dismutase 1 protein (ab90040)

ab90040 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

As indicated in the protocol booklet and on the datasheet, this kit does indeed not include the SOD standard.

However, as a standard, your client may want to use ab90040 Superoxide Dismutase 1 protein (...

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Vielen Dank für Ihre Geduld.

Es tut mir sehr leid, jedoch auch nach mehrmaligem Nachfragen, konnte ich die genaue Aktivität des Proteins ab90040 in Erfahrung bringen. Ich kann jedoch bestätigen, dass die Aktivität> 2.00...

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