Mediator of RNA polymerase II transcription subunit 21
RNA polymerase II holoenzyme component SRB7
RNAPII complex component SRB7
SRB7 suppressor of RNA polymerase B homolog
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Belongs to the Mediator complex subunit 21 family.