Recombinant Human SUV420h1 protein (ab80286)

Overview

  • Product nameRecombinant Human SUV420h1 protein
  • Protein lengthProtein fragment

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • Amino acids2 to 387

Specifications

Our Abpromise guarantee covers the use of ab80286 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 30% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0

General Info

  • Alternative names
    • CGI 85
    • CGI85
    • Histone-lysine N-methyltransferase KMT5B
    • Kmt5b
    • KMT5B_HUMAN
    • Lysine N-methyltransferase 5B
    • Lysine-specific methyltransferase 5B
    • MGC118906
    • MGC118909
    • MGC21161
    • MGC703
    • Su(var)4-20 homolog 1
    • Suppressor of variegation 4 20 homolog 1
    • Suppressor of variegation 4-20 homolog 1
    • Suv4-20h1
    see all
  • FunctionHistone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3.
  • Sequence similaritiesBelongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.
    Contains 1 SET domain.
  • Cellular localizationNucleus. Chromosome. Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity).
  • Information by UniProt

Recombinant Human SUV420h1 protein images

  • SDS-PAGE showing ab80286 at approximately 70kDa (3µg).

References for Recombinant Human SUV420h1 protein (ab80286)

ab80286 has not yet been referenced specifically in any publications.

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