Recombinant Human Synphilin 1 protein (ab160582)

Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      MTYLIQSHHSRRSQNCAEDVIRKTKTDQNGQLECVRWMVSETEAIAELSC SKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQ HGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCM SLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSS PASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDS DKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLAR LRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMGSAES LHLMIKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGS GSIPPNQPSGDPQQPSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRV TFEEPVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGDQLKRPFGAFRS IMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRKTDAKGNPASSASKGKN KAEMYSSCINLSSNMLIEEHLCNDTRHNDINRKMKKSYSIKHIAEPESKE LFL
    • Amino acids
      1 to 603
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab160582 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • Alpha synuclein interacting protein
    • Alpha-synuclein-interacting protein
    • MGC39814
    • SNCAIP
    • SNCAP_HUMAN
    • Sph1
    • Synphilin-1
    • Synphilin1
    • Synuclein alpha interacting protein
    • Synuclein alpha interacting protein (synphilin)
    • SYPH 1
    see all
  • Function
    Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1.
  • Tissue specificity
    Detected in brain (at protein level). Widely expressed, with highest levels in brain, heart and placenta.
  • Involvement in disease
    Parkinson disease
  • Sequence similarities
    Contains 6 ANK repeats.
  • Post-translational
    modifications
    Ubiquitinated; mediated by SIAH1, SIAH2 or RNF19A and leading to its subsequent proteasomal degradation. In the absence of proteasomal degradation, ubiquitinated SNCAIP accumulates in cytoplasmic inclusion bodies. Isoform 2 is subject to limited ubiquitination that does not lead to proteasomal degradation.
  • Cellular localization
    Cytoplasm. Detected in cytoplasmic inclusion bodies, together with SNCA.
  • Information by UniProt

Images

  • ab160582 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab160582 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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