Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • AccessionQ15370
    • SpeciesHuman
    • SequenceMDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCIEPFSSPPELP DVMKPQDSGS SANEQAVQ
    • Molecular weight13 kDa
    • Amino acids1 to 118

Associated products

Specifications

Our Abpromise guarantee covers the use of ab117680 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    TCEB2 is purified by standard chromatography techniques and filter sterilized.
  • FormLiquid
  • Additional notesFor long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.02% PMSF, 20% Glycerol

General Info

  • Alternative names
    • EloB
    • ELOB_HUMAN
    • Elongin 18 kDa subunit
    • Elongin B
    • Elongin-B
    • RNA polymerase II transcription factor SIII p18 subunit
    • RNA polymerase II transcription factor SIII subunit B
    • SIII
    • SIII p18
    • TCEB 2
    • Tceb2
    • Transcription elongation factor B (SIII) polypeptide 2
    • Transcription elongation factor B polypeptide 2
    see all
  • FunctionSIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 1 ubiquitin-like domain.
  • Cellular localizationNucleus.
  • Information by UniProt

References for Recombinant Human TCEB2 protein (ab117680)

ab117680 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab117680.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"