Overview

Description

  • NatureRecombinant
  • SourceEscherichia coli
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceMDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVQ

Associated products

Specifications

Our Abpromise guarantee covers the use of ab81767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    SDS-PAGE

  • Purity> 95 % SDS-PAGE.
    ab81767 recombinant TCEB2 was expressed as insoluble protein aggregate in E.coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 20% Glycerol, 0.1M PMSF, 20mM Tris HCl, 1mM DTT, pH 8.0

General Info

  • Alternative names
    • EloB
    • ELOB_HUMAN
    • Elongin 18 kDa subunit
    • Elongin B
    • Elongin-B
    • RNA polymerase II transcription factor SIII p18 subunit
    • RNA polymerase II transcription factor SIII subunit B
    • SIII
    • SIII p18
    • TCEB 2
    • Tceb2
    • Transcription elongation factor B (SIII) polypeptide 2
    • Transcription elongation factor B polypeptide 2
    see all
  • FunctionSIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex).
    The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesContains 1 ubiquitin-like domain.
  • Cellular localizationNucleus.
  • Information by UniProt

Recombinant Human TCEB2 protein images

  • ab81767 on 15% SDS-PAGE (3µg)

References for Recombinant Human TCEB2 protein (ab81767)

ab81767 has not yet been referenced specifically in any publications.

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