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Product name Recombinant Human TCF3 / E2A protein
Protein length Protein fragment Description
Source Wheat germ
Amino Acid Sequence
Sequence EREKERRVANNARERLRVRDINEAFKELGRMCQLHLNSEKPQTKLLILHQ AVSVILNLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQMVLSAPHPGL SEAHNPAGHM
Molecular weight 38 kDa including tags
Amino acids 545 to 654 Specifications
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Additional notes Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
Concentration information loading... Preparation and Storage
Stability and Storage
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Constituents: 0.3% Glutathione, 0.79% Tris HCl
Class B basic helix-loop-helix protein 21
Function Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
Involvement in disease Note=Chromosomal aberrations involving TCF3 are cause of forms of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with PBX1; Translocation t(17;19)(q22;p13.3) with HLF. Inversion inv(19)(p13;q13) with TFPT.
Sequence similarities Contains 1 basic helix-loop-helix (bHLH) domain.
Domain the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Post-translational modifications Phosphorylated following NGF stimulation.
Cellular localization Nucleus.
Information by UniProt
Recombinant Human TCF3 / E2A protein images
References for Recombinant Human TCF3 / E2A protein (ab114447)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"