Overview

Description

  • Nature
    Recombinant
  • Source
    Wheat germ
  • Amino Acid Sequence
    • Species
      Human
    • Sequence
      RNHPTRLSLVFYQHKNLNKPQHGFELNKIKFEAKEAKNKKMKASEQKDQA ANEGPEQSSEVNELNQIPSHKALTLTHDNVVTVSPYALTHVAGPYNHWV
    • Amino acids
      2038 to 2136
    • Tags
      proprietary tag N-Terminus

Specifications

Our Abpromise guarantee covers the use of ab153524 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    ELISA

    Western blot

  • Form
    Liquid
  • Additional notes
    Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

General Info

  • Alternative names
    • bA119F7.1
    • CXXC 6
    • CXXC finger 6
    • CXXC type zinc finger protein 6
    • CXXC zinc finger 6
    • CXXC-type zinc finger protein 6
    • CXXC6
    • KIAA1676
    • LCX
    • Leukemia associated protein with a CXXC domain
    • Leukemia-associated protein with a CXXC domain
    • Methylcytosine dioxygenase TET1
    • Ten eleven translocation 1
    • Ten eleven translocation 1 gene protein
    • Ten eleven translocation 1 gene protein homolog
    • Ten-eleven translocation 1 gene protein
    • Tet 1
    • Tet methylcytosine dioxygenase 1
    • Tet oncogene 1
    • TET1
    • TET1_HUMAN
    see all
  • Function
    Dioxygenase that catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). Plays a role in embryonic stem (ES) cell maintenance and inner cell mass (ICM) cell specification, possibly by participating in DNA demethylation. Specifically binds 5mC, a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. 5mC is present in ES cells and is enriched in the brain, especially in Purkinje neurons. The clear function of hmC is still unclear but it could constitute an intermediate component in cytosine demethylation. A role of hmC in DNA demethylation is supported by TET1 function in ES cell maintenance, which is required to prevent NANOG hypermethylation and maintain NANOG expression in ES cells.
  • Tissue specificity
    Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. Not detected in adult heart, lung or brain.
  • Involvement in disease
    Note=A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5' MLL-TET1 3'.
  • Sequence similarities
    Belongs to the TET family.
    Contains 1 CXXC-type zinc finger.
  • Cellular localization
    Nucleus.
  • Information by UniProt

Images

  • ab153524 on a 12.5% SDS-PAGE stained with Coomassie Blue.

References

ab153524 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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