The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab177603 was purified by using anion-exchange chromatography (DEAE sepharose resin) and gel-filtration chromatography.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Information available upon request.
TGF-beta receptor-associated protein 1
Transforming growth factor-beta receptor-associated protein 1
Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.
Belongs to the TRAP1 family. Contains 1 CNH domain.
Cytoplasm. Colocalizes with TGF-beta receptors in the absence of signaling.